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Adult: The usual recommended intial and maintenance dose is Irtan Plus once daily.
Doses higher than 300 mg irbesartan/25 mg hydrochlorothiazide once daily are not recommended. When necessary, Irtan Plus may be administered with another antihypertensive drug.
Due to the hydrochlorothiazide component, Irtan Plus is not recommended for patients with severe renal dysfunction (creatinine clearance <30 mL/min).
No dosage adjustment is necessary in patients with renal impairment whose renal creatinine clearance is ≥30 ml/min.
Hepatic impairment and elderly patients.
